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Acetylcholinesterase Active Site Cube©
Acetylcholinesterase Active Site Cube<sup>&#169;</sup>
Acetylcholinesterase Active Site Cube©

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Starting at: $499.00

Grade Levels
High School

Choking Hazard
Small Magnets
Science Education Product
California Proposition 65

Quantity in Stock:1
Availability: Due to a Delay, this Item will Ship in 1 to 2 Weeks
Product Code: ACHASC

AChE Cubes:
3'' Plaster Cube
5'' Plaster Cube

Description Contents Teacher Resources

This plaster mini model is being discontinued as we redesign it for 3D printing in a larger size and a more durable material. Best of all, we believe we will be able to offer it at a lower price! Watch for its updated availability on our Facebook page, Instagram, and eNewsletter.

What better way to illustrate what happens inside an enzyme than with this 3-D model of acetylcholinesterase? Unfold the cube to show the amino acids in the active site and demonstrate how an insecticide affects the enzyme.

Acetylcholinesterase is responsible for cleaving the excess neurotransmitter, acetylcholine, from synapses. As your students unfold the Acetylcholinesterase Active Site Cube© they will see how tightly amino acids are packed in a protein. They will also discover how 3 amino acids in the active site bind the substrate (acetylcholine) and collaborate to cleave the neurotransmitter. The acetylcholinesterase gene and the protein it encodes can be used to demonstrate a number of biological concepts including:

  • Enzyme specificity
  • Competitive inhibition
  • Effect of mutations on protein structure
  • How natural selection results in the emergence of insecticide-resistant mosquitoes from a wild population

The substrate, insecticide and mutant amino acid side chain bind to the enzyme with magnets.

The 1936 Nobel Prize in Physiology or Medicine was awarded jointly to Sir Henry Hallett Dale and Otto Loewi "for their discoveries relating to chemical transmission of nerve impulses". Sir Henry Hallett Dale discovered that acetylcholine is produced naturally in the body. By developing methods for extracting acetylcholine from animal tissues Dale and his colleagues carried out a series of experiments that revealed how the chemical works.

The 5” model comes with acetylcholine, insecticide and a mutant side chain, which bind to the enzyme with magnets. It is made of plaster by rapid prototyping and should be handled with care. Models will break if dropped, held tightly or handled roughly. Its PDB file is 1QON.pdb.

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