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ß-Globin Folding Kit©
ß-Globin Folding Kit<sup>&#169;</sup>
ß-Globin Folding Kit©

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Protein-Folding Kit

Starting at: $149.00

Grade Levels
High School

Students per Group
6-9 Students per Kit
3 Groups of 2-3 Students

Choking Hazard
Small Magnets
Science Education Product
California Proposition 65

Availability: Due to a Delay, this Item will Ship in 2 to 4 Weeks
Product Code: BGFK

Description Contents Teacher Resources

ß-globin becomes real in your students’ hands as they fold mini toober fragments into a 3-D protein model of ß-globin. Your students will discuss oxygen transport as they attach O2 to the iron in the heme group and then explore how a single mutation causes sickle cell anemia.

This advanced protein-folding kit reinforces lessons introduced in 3DMD’s Amino Acid Starter Kit, and then allows your students to explore structure and function.

Small teams first focus on the structure of ß-globin by:

  • Using folding maps to mark selected amino acids (primary structure) and alpha helices (secondary structure)
  • Folding the protein into its 3-D tertiary structure, adding connectors for stability
  • Assembling the 3 fragments together to form the ß-globin protein
  • Adding the heme group with an iron atom and O2

After exploring oxygen transport, your students can remove the glutamic acid at position 6 on the ß-globin model and replace it with valine. The single-point mutation from a negatively charged amino acid to a hydrophobic one causes red blood cells to clump together and assume the sickle cell shape.

The kit includes 3 mini toobers (red, green, and blue), 3 color-coded laminated folding maps, 4 color-coded bags (blue, green, red, and yellow) containing parts to mark and connect the fragments in the 3-D protein structure, 3 laminated Amino Acid Side Chain Charts and 3 wooden dowels. The ß-Globin Folding Kit can be used successfully by 6 to 9 students working in 3 teams.

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