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Neurotransmitters Module: The Beery Twins’ Story
Neurotransmitters Module
Neurotransmitters Module: The Beery Twins' Story


 
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You can use maps and models separately or together!
Starting at: $19.00

Grade Levels
High School
College

Students per Group
2 - 4 Students

Warnings
Choking Hazard
Small Magnets
Science Education Product
California Proposition 65



Availability: Please allow 4 weeks for production and shipping of plaster models.
Product Code: NM


Neurotransmitters Module:
1 Student 1 Teacher SPR Map Set $19.00
3 Student 1 Teacher SPR Map Set $40.00
6 Student 1 Teacher SPR Map Set $75.00
Sepiapterin Reductase Mini Model $137.00
Dopamine Biosynthesis Model $37.00
Serotonin Biosynthesis Model $39.00

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Description Contents Teacher Resources
 

Captivate your students and cover a wide range of science topics with the true story of California twins Noah and Alexis Beery, who have gene variants that cause them to have life-threatening low levels of three neurotransmitters. Whole genome sequencing in 2010 identified a mutation in the gene that encodes the sepiapterin reductase enzyme, leading to a molecular diagnosis and successful treatment.

Human Sepiapterin Reductase mRNA Gene Map

This gene map presents the nucleotide sequence of the messenger RNA encoding sepiapterin reductase - the enzyme that was shown to be defective in Noah and Alexis Beery. The map documents the molecular consequence of two different mutations in this gene that were responsible for the neurotransmitter deficiencies experienced by the Beery twins. Student maps can be used by individuals or small groups and are available in sets of 1, 3 or 6. One teacher's map comes with every set. The teacher’s map features highlighted reading frames and mutation sites. All maps are laminated.

Sepiapterin Reductase Mini Model

Show your students a physical representation of the twins' genetic mutations and neurotransmitter deficiencies. Three small, magnet-docked sections of our Sepiapterin Reductase Mini Model are removable, revealing the two mutations that the twins inherited from their parents and the cofactor needed for the production of the neurotransmitters.

Dopamine and Serotonin Biosynthesis Models

These models show how two amino acids (tyrosine and tryptophan) are converted into two neurotransmitters (dopamine and serotonin) by two consecutive enzyme-catalyzed reactions. Magnet-docked hydroxyl groups, carboxylate groups and hydrogens allow each model to be quickly converted from amino acid to neurotransmitter in two easy steps. These structures were determined with the National Institute of Health databank. The models are made of plaster by 3-D printing and should be handled with care. They will break if dropped, held tightly or handled roughly.


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